Viagra could cut heart stress

February 29th, 2008

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anti-impotence drug Viagra can reduce the effects of stress on the heart, research has found.

The drug, used by millions of men, slowed the increase in the strength of heart dysfunction erectile pill
s by half.

The Johns Hopkins University study, published in Circulation, found the drug acted as a “brake”.

However, UK heart experts warned men with heart conditions should talk to their doctor about taking the drug to ensure they use it safely.

Mixing this drug with other heart medicines or taking it if you have angina without advice from a health professional or GP can be dangerous for heart patients

Dr Charmaine Griffiths, British Heart Foundation

Viagra, also known as sildenafil, helps men with erectile dysfunction by making genital blood vessels expand in order to maintain an erection.

The Johns Hopkins team have previously shown Viagra can block the short-term effects of hormonal stress in the heart in mice.

But it had been thought to have little direct effect on the human heart.

Contractions

This study looked at 35 men and women, with an average age of 30 and no previous signs of coronary artery disease.

They were all given an injections of an viagra impotence pill chemical called dobutamine, which increases heart rate and pumping strength in the same way as emotional or exercise stress, or heart failure.

They were then randomly assigned to either take 100mg of Viagra or a dummy pill before receiving a second injection. Heart function was measured before and after each jab.

After the first injection of dobutamine, the force of heart contraction increased by 150% in both groups.

In the dummy pill group, the same effect was seen after the second injection.

However, in the group treated with Viagra the increased heartbeat was slowed by 50%, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation.

No adverse side effects on the heart were seen.

Viagra helps maintain erections by blocking the action of an enzyme which prevents the relaxation of blood vessels in the penis.

The same enzyme, called erectile dysfunction drugs
5 (PDE5A), is also involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit heart enlargement.

Heart warning

Professor David Kass, the cardiologist who led the study, said: “Sildenafil effectively puts a 'brake' on chemical stimulation of the heart.”

He added: “Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems.

“Until now, it was widely thought that drugs like sildenafil had no effects on the human heart and that its only purpose was vasodilation in the penis and the lungs.”

He said further studies should be carried out to impotence pump Viagra's immediate and long-term effects on the heart.

Dr Charmaine Griffiths, from the British Heart Foundation, said: “Viagra has been a real advance in treating impotence, which affects nearly half of men between 40 and 70 years old.

“The findings that Viagra affects blood pressure is not surprising - before it was known as a successful treatment for impotence, it was actually being researched for lowering effects on blood pressure.”

But she added: “If you have a heart condition you should check with your doctor before taking Viagra.

“Mixing this drug with other heart medicines or taking it if you have angina (heart pain on exercise) without advice from a health professional or GP can be dangerous for heart patients.”

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News - Prostate cancer news ‘by phone’

February 28th, 2008

One in five men diagnosed with prostate cancer are told the news in an insensitive way - some by phone or letter, a survey has found.

The Prostate Cancer Charity asked over 1,140 men about their diet for impotence
.

Just under a quarter of those who were alone when they heard their diagnosis wished someone had been with them.

And almost 20% were not made aware of the side effects of different prostate cancer treatments, which can include impotence and incontinence.

And 40% said they were not given written information about the disease, treatments or side effects such as impotence to take away with them.

The Prostate Cancer Charity said the survey findings, which it launched at a penis pump for erectile dysfunction
in London this week, highlighted the wide variations in care that men received.

Every year, over 30,000 men are diagnosed with the disease and 10,000 men die from it.

It is now the most common cancer diagnosed in men in the UK.

'Anger and frustration'

Chris Hiley, head of policy and research at the Prostate Cancer Charity, said: “We must improve all men's experiences of health care choices. Help them demand attention.

“Change society's views so men's entitlement to tailored health care is as respected as women's.”

John Neate, chief executive of the charity, said: “Many men singled out doctors and nurses who gave them fantastic care.

“But all too often the comments described men's anger and frustration.”

He added: “It's disgraceful that so many men with prostate cancer still do not get impotence treatment uk care and support.

“One man told us how he received a letter on a Saturday telling him he had cancer, with a help number that was not available until the following Monday.

“Another man commented: 'Although I had disgraceful attention, I have been lucky with no serious effects'.”

He called on the impotence zinc to make prostate cancer a more urgent priority.

Professor Jessica Corner, of the charity Macmillan Cancer Relief, said: “Men's vital needs are not being met and more appropriate care, support and advice is crucial to their well-being.

“Only over the past five years has the NHS invested resources into prostate cancer compared to breast cancer for example and this needs to change.”

“With more research, resources and greater awareness, men could start to see an improvement in prostate cancer services.”

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Steroid use highest in valleys

February 27th, 2008

erectile dysfunction

Former mining improve erectile dysfunction
in south Wales have the worst levels of steroid abuse in the UK, research seen by the BBC has shown.

A survey by the Impotence
of Glamorgan found as many as seven out of 10 people using gyms in the region take drugs to help their training.

More inactive lifestyles mean people are turning to steroids to get the shape they want, the study author says.

The research is unveiled on the BBC Radio Wales programme Eye on Wales.

Professor Bruce Davies carried out the research in gyms dedicated to heavy lifting in the south Wales valleys area, and says the findings replicate those of studies carried out in other parts of Wales.

He said: “We found by going into big lifting gyms that 70% of the attendants were using anabolic steroids.

“We've seen very similar studies in north Wales, in Cardiff and in Swansea, so I suspect there's a significant number of people using anabolic steroids in Wales.”

Impotence in male of the drugs can include baldness, impotence, developing milk-producing breasts in men and acne, and in misuse of anabolic steroids can cause heart and liver failure.

Professor Davies believes use has risen in former mining areas because of social changes.

“Gone are the days when you could get admiration by going down a mine -you didn't have to prove anything,” he said.

“Sadly those days are gone and now people are seeking other ways to gain admiration.

“When you think about it these days, most people are semi-debauched, we're not a very active society so the only way to acquire the muscles these people want is to weight train using anabolic steroids.”

Dealing

One 20-year-old weight-training enthusiast, who gained five stone in three years after taking steroids, thinks the risks of the drug have been overstated.

“It's down to the individual - if your diet's good and your training's good you should be fine,” he said.

“Ok, something could go wrong inside but that could happen to a normal person walking down the street. A lot of the risks are just word of mouth and I think a lot of things are exaggerated totally out of treating impotence
.”

Possession and use of steroids is not illegal, provided it is a “medicinal form”, but dealing steroids is.

Katy Swaine, head of legal services at drug charity Release, thinks there is some ambiguity about what impotence remedy a medicinal form of the drug.

“The law on steroids still remains in a slightly unclear state and could certainly do with clarification now,” she said.

The research, entitled Steroid and Prescription Medicine - Abuses in the Recreational Gym user - a regional study, questioned 210 people at 100 heaving lifting gyms in the former Mid Glamorgan county area in 2005.

Eye on Wales is broadcast on BBC Radio Wales on Monday 3 July at 1800 BST.

NOTE: Side-effects of the drugs can include baldness, impotence, developing milk-producing breasts in men and acne, and in misuse of anabolic steroids can cause heart and liver failure.

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Push for over-the-counter Viagra

February 26th, 2008

erectile dysfunction

The anti-impotence pill Viagra could be available over-the-counter drug, it is reported.

The drug's maker Pfizer says it is considering submiting an application to European regulatory man erectile dysfunction
to clear it for sale in pharmacies.

An estimated 27 million men have already used the little blue pill for erectile diabetic impotence on prescription.

Medics said a change would be welcome but might mean other linked diseases were missed with no health check ups.

Ups and downs

Often, men with erectile dysfunction have underlying health problems such as diabetes, which can be spotted by their GP at the time they come for an anti-impotence prescription.

“If men can buy Viagra and rival anti-impotence drugs over-the-counter without a prescription, this treat for impotence
is missed,” said Dr David Ralph from the Institute of Urology at University College London.

But there would be benefits too, he said, such as combating the problem of Viagra sold illegally on the internet from unknown sources, which may be fake and if taken with some medicines could be fatal.

He said it would be safe to buy over-the-counter provided the pharmacist did the necessary checks to ensure the medication was suitable for the patient.

Embarrassment factor

It might also be a more attractive option to men as going to see the GP about sexual problems can be embarrassing, he added.

But he cautioned: “There is more to sexual relations than an erection. There may be other problems.”

Viagra works by relaxing the blood vessels in the penis. This allows blood to flow into the penis causing an erection.

However, the drug is not an aphrodisiac and does not increase sex drive.

It is licensed only as a treatment for men who have been diagnosed by a doctor as having impotence.

Also, some men, such as those with severe heart disease or low blood pressure, should avoid it because of possible risks and side effects.

Viagra is not licensed for use in women and its safety in women has not been ejaculatory impotence.

A Pfizer spokesman said: “As with many of our products, Pfizer has routinely evaluated a number of options including different formulations, new indications, over-the-counter and continues to do so.”

He added that despite speculation there were no plans to pursue a spray version of the drug.

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Pelvic floor exercises help men and work as viagra

February 25th, 2008

erectile dysfunction

Pelvic floor exercises have long been recommended for women - now researchers say they could help men too.

The exercises were found to help men with erectile dysfunction as much as taking in Viagra.

The researchers say the findings mean men have an impotence in male to drug therapy.

For around 50 years, women have been advised to perform pelvic floor exercises to strengthen their muscles for childbirth.

The pelvic floor is a “hammock” of muscles which support the bowel and bladder.

Pelvic floor, or Kegel, exercises involve clenching the muscles you would use to prevent yourself urinating.

This latest research indicates it is also important for men to maintain the muscle tone and function of their pelvic floor muscles with the exercises.

Home exercises

The team from the University of the West of England in Bristol studied 55 men with an average age of 59 who had experienced erectile dysfunction for at least six months.

The men, all patients at the Somerset Nuffield Hospital, Taunton, Somerset, were given five weekly sessions of pelvic floor exercises and assessed at three and six months, and asked to practise the exercises daily at home.

It was found 40% of the men regained normal erectile function - some of who had severe erectile dysfunction, and another 35% showed some male sexual dysfunction.

Two thirds of the men had said they also had problems with urination. These improved significantly after they began the exercises.

Dr Grace Dorey, a specialist continence physiotherapist who carried out the research, told BBC News Online: “The exercises were found to be equally as effective as taking Viagra.

“Pelvic floor exercises improve function in a physical way, in a more natural way.

“Men should be doing impotence sex
exercise. It really is use it or lose it.”

She said men should be exercising their pelvic floor exercises from puberty onwards.

Strength

A cialis tadalafil generic rezeptfrei
for the Impotence Association said: “The value and effectiveness of pelvic floor exercises should not be erectile dysfunction and young man
when considering the management of sexual problems such as impotence and premature ejaculation.

“The exercises are thought to strengthen the muscles that surround the penis and improve the blood supply in the pelvis, which is an important factor in relation to erectile dysfunction.”

The Impotence Association helpline number is 0208 767 7791.

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Smoking is unsexy and increases the risk of erectile dysfunction

February 24th, 2008

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Risqu TV, radio and billboard ads will be appearing across the UK from July to drill home the message to young people that smoking is not sexy.

One of the government-funded images carries the strapline “Your penis thinks you should stop smoking” to highlight the risk of impotency.

Ministers say fears about fertility and attractiveness are stronger high blood pressure impotence for young people to quit than health.

A survey suggests one in two smokers would quit to improve their sex appeal.

The NHS Smoking Helpline drug for impotence levitra also revealed that more than two-thirds of young men and women believe smoking makes them less attractive.

Half of men said they impotence psychological cause smoking with wrinkles, bad skin and less enjoyable kissing.

Another of the ads shows stark images of the effect of smoking on women's appearance and attractiveness to men, with messages such as “If you smoke, you stink”, “Minging teeth” and “Cat's bum mouth”.

Websites called “Staying Hard” and Ugly Smoking” will also be launched, alongside a sticker campaign in pub and club toilets.

Public Health Minister Caroline Flint said: “This latest series of adverts marks a new and exciting route for the campaign.

“A key part of our drive to reduce overall smoking prevalence is getting the message to male sexual dysfunction young adult audiences.

Hard-hitting

“We know 70% of smokers want to stop smoking; however, with younger people, fears about attractiveness and fertility can be a stronger motivation to quit than fears about health.

“It is hoped that the hard hitting messages in this new campaign will make young people quit smoking for good.”

One of the advertisements
Smoking can damage your teeth

Smoking increases the risk of erectile dysfunction by around 50% for men in their 30s and 40s and up to 120,000 men from the UK in this age group are impotent as a direct result of smoking, experts estimate.

Clive Gingell, chairman of the Sexual Dysfunction Association, said: “By making men aware of how smoking can affect their sexual performance in middle age, hopefully this new campaign should provide men with an additional and compelling reason to quit.”

Dr Bav Shergill, from the British Skin Foundation, said: “Giving up smoking can not only add years to your life, it also adds years to your appearance and can help stop premature aging before it's too late.”

However, Simon Clark, director of the smokers' lobby group Forest, said: “To try and suggest that smoking is a major cause of impotence is a scare tactic.

“It's nasty because it is not only setting out to de-normalise smoking, but really to make smokers feel incredibly guilty about their habit.”

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Doctor cleared over impotence treatment creams

February 23rd, 2008

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A Harley Street doctor has been cleared over his prescription of expensive impotence remedies which did not work.

Dr Moloy Prakash Sahu, who worked at the Wellman Clinic, 57 Harley Street, for a year, faced several allegations.

These ranged from providing treatment without medical justification to “irresponsible prescribing”.

The General Medical Council said his practice was “less than satisfactory” but did not amount to serious diabetic impotence misconduct.

'Boost'

The four-day hearing was held after three patients at the clinic complained to the GMC.

It heard that the average patient was given a three-month course of impotence treatment made up of vitamins, creams and washes, costing 1,500 to 2,000 - many of which were “useless if not dangerous”.

One of the three was prescribed a drug which, mixed with an anti-depression drug he was already taking, could have proved fatal.

That patient was also treated for a condition he did not suffer.

Dr Sahu denied it was “irresponsible” to prescribe the drug Yohimbin to one man, saying: “He had erectile problems and it is a medicine you can give.”

He also said his employers at the clinic insisted vitamin injections be given as a matter of policy.

Dr Sahu admitted the “harmless” injection was a placebo and that he never told patients it had no medical justification, but said it could give a patient “a bit of a boost”.

'Less than satisfactory'

Dr Sahu, of Treat for impotence
, east London, worked at the clinic as medical officer between July 2000 and June 2001.

He said he became “cream for erectile dysfunction
” and quit the post because the clinic was badly managed and poorly equipped.

Dr Sahu was cleared of failing to ensure his patients were given sufficient information about their conditions, and failing to keep proper drug records.

The doctor was also acquitted of treating patients without the required expertise and failing to make sure patients gave proper or informed consent for treatment.

A number of other allegations were withdrawn following legal submissions.

The hearing's chairman John Shaw said: “These reimpotence and alcohol
taken together did not cross the threshold of serious professional misconduct.

“The committee therefore finds you not guilty of serious professional misconduct.”

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Offenders can be denied viagra.

February 22nd, 2008

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US states have been told they do not have to pay to provide the impotence drug Viagra to convicted sex offenders.

The move comes after an audit found 198 convicts in New York state had been newest impotence medicine by Medicaid for the drug between January and March 2000.

Their crimes included offences against children as young as two.

The Medicaid programme, whose cost is shared by states and the federal government, provides health care for the poor.

The federal Centres for Medicare and Medicaid Services said they should not pay for erectile dysfunction drugs for sex offenders.

Spokesman Gary Karr said “states already have the power to determine if a drug is not medically appropriate for a certain patient or certain class of patients”, the Associated Press news agency reported.

“Public risk”

The New York audit, conducted by Comptroller Alan Hevesi, did not cover other states, but Mr Hevesi said states are required by law to include Viagra in Medicaid programmes covering new impotence drug drugs when medically necessary.

He said the policy raised “serious policy considerations and has the potential to place the public at risk” and asked the government to take curing impotence action or amend the Medicaid law.

On Monday, Florida Attorney General Charlie Crist said that Medicaid had paid $93,000 to provide Viagra to 218 sex offenders in that state over the last four years, AP reported.

New York Senators Charles Schumer and Hillary Clinton have both indicated they back a change in policy.

Sen Schumer said: “It is just male sexual erectile dysfunction
to think that Level 3 sexual offenders can get Viagra, which may indeed help them perpetrate other horrible crimes.

“Giving convicted sex offenders cialis and erectile dysfunction
Viagra is like giving convicted murderers an assault rifle when they get out of jail,” Schumer said.

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Doctor sold useless sex creams

February 21st, 2008

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A Harley Street doctor prescribed expensive impotence remedies which were useless if not dangerous, a GMC impotence conditions hearing has been told.

Dr Moloy Prakash Sahu of the Wellman Clinic, 57 Harley Street, gave creams and pills which had “no evidence” of treating sexual problems, it heard.

He failed to check medical histories or possible impotence problem problems, said expert witness Laurence Sandler.

Dr Sahu denies serious fact male impotence misconduct. The hearing continues.

Mr Sandler, of Wycombe General Hospital, said he had examined patient records and notes made by Dr Sahu and could not understand the drugs and other preparations that had been prescribed.

He noted Dr Sahu had spent little time talking through the sex problems of his patients before prescribing.

“I spend a long time talking to them. It is very difficult but you have to get a rapport with them. It is a very sensitive problem,” said Mr Sandler.

Psychological factors

Mr Sandler said the cause of low libido was often psychological, or caused by factors such as high blood pressure, smoking and drinking.

But Dr Sahu had failed to discuss this in detail with the patients, he said.

There was an average of a three month course of treatment made up of vitamins and washes for each man and the cost would be in the region of 1,500 to 2,000

Lynn Griffin, for the GMC

Mr Sandler also warned about Dr Sahu's prescriptions for the sex drug Viagra.

“There is a significant failure rate. It isn't a catch-all. It doesn't work all the time.”

The hearing was held after three patients at the clinic, which charges up to 2,000 a time for treatment, complained to the GMC.

Earlier, it was told that one patient who complained that a 12 week course of treatment had failed to work was “flabbergasted” by an invitation to sign up for another course.

Another was prescribed a drug which, mixed with an impotence forum
drug he was already taking, could have proved fatal.

That patient was also treated for a condition he did not suffer.

'True purpose'

Lynn Griffin, for the GMC, said Dr Sahu targeted “vulnerable men” suffering impotence problems to earn “ridiculous amounts of money”.

She said the doctor's “deference” to non-medically qualified members of the clinic's staff illustrated the “true purpose” of the establishment.

That “was to get vulnerable men to part with money for treatment which was not effective and certainly overpriced,” she said.

This clinic appears to have a standard form of treatment which is meted out regardless of the condition presented by the patient

Lynn Griffin
GMC

Dr Sahu prescribed a range of vitamins, herbal washes, creams and other drugs which were on the whole “healing herbal impotence“, she said.

Often his contact with patients was “minimal”, while other staff persuaded them to sign up for treatments.

Ms Griffin also said the price of the treatments appeared excessive.

“There was an average of a three month course of treatment made up of vitamins and washes for each man and the cost would be in the region of 1,500 to 2,000,” she said.

Charges denied

She said despite each patient suffering a range of problems, the men were given similar treatment.

“This clinic appears to have a standard form of treatment which is meted out regardless of the condition presented by the patient.

“For most patients the prescribing was inappropriate - the drugs would have been ineffective and no matter how many washes and creams were given to these gentlemen along with these medications it would not have assisted their problem,” said Ms Griffin.

One patient told the hearing the clinic had since paid the costs of his treatment, plus interest, as a result of a small claims court ruling.

Dr Sahu, of Walthamstow, East London, denies 11 charges amounting to serious professional misconduct, arising from his treatment of patients at the clinic between July 2000 and June 2001.

The hard sell viagra

February 20th, 2008

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The rise and rise of Viagra has created a 1.5bn worldwide market in erectile dysfunction help
pills.

Now rivals are fighting for a share of the spoils and it is becoming a vacuum device for erectile dysfunction drug of choice for some in the party generation.

Last week, Pfizer's chief executive Henry McKinnell warned that Chinese made counterfeits posed a threat to its business and urged the country's authorities to clamp down on the copycats.

New research

Pfizer, the world's biggest pharmaceutical company, stumbled on the drug by accident at their research labs in Sandwich, Kent.

In the late 1980s, they had been developing a new treatment for angina, but noticed a strange side-effect in trials - increased erections among volunteers.

The effect on their sex lives was so marked that once the angina trails were over the volunteers wanted to keep on taking the medication.

Pfizer decided to commission some new research.

In 1989 they approached Clive Gingell, one of Britain's top Urological Surgeons, based in Bristol.

He had spent his whole career trying to treat and improve the lives of thousands of men suffering from impotence.

In those days, commonly used treatments included the fitting of implants directly into the penis, a vacuum pump and self injection.

Most sufferers were thoroughly put off and consigned themselves to a life without sex.

Viagra arrives

Mr Gingell ran a new series of trials, and the results impressed him.

Pfizer chief executive Henry McKinnell
Pfizer chief executive McKinnell says copycats pose a threat

He describes Viagra as “a wonder drug”.

“The thought of having a pill that would cure impotence was amazing to me,” he says.

“I never thought I would see it in my lifetime.”

“There has been a kind of Holy Grail idea associated with curing impotence,” Pfizer's Mariann Caprino tells the Money Programme.

“And here it was in a little blue pill.”

Colossal market

When Viagra was launched in 1998, Pfizer's share price doubled. It was apparent that there was a huge previously untapped market out there.

Doctors claim that half of all men over 40 become impotent at some point in their lives.

That is more than 150 million worldwide, with two million sufferers in Britain alone, so the potential market for drugs like Viagra is colossal.

Overnight Viagra made Pfizer famous. “We discovered the mass production of penicillin, yet it was Viagra that put Pfizer on the map,” says Ms Caprino.

Embarrassing subject

Nevertheless, despite the highly successful launch, the company faced a huge potential problem in selling Viagra.

Men were simply not willing to talk about impotence, they were ashamed.

If they were not prepared to discuss their impotence, how could they be persuaded to ask their doctor for a alternative impotence treatment?

Ray Reynolds, who suffered from impotence for 30 years, had simply given up hope of ever being able to have sex again.

“I thought well, I'll just put it to one side and remain a eunuch for the rest of my life,” he says.

Celebrity endorsement

To overcome the problem, Pfizer came up with a series of marketing ploys.

Viagra-sponsored car
Pfizer sponsors NASCAR, America's top spectator sport

Firstly, they asked the Vatican, and other world religious leaders, for their blessing. This headed off possible moral and religious objections.

Secondly, they employed big name celebrities to encourage men to seek treatment for impotence.

Pele, the legendary footballer, headed a men's health campaign about erection problems, and 75 year old former US Presidential candidate Bob Dole went public for Pfizer about his own impotence problem.

American men rushed to their doctors.

Leon Steinberg, an 84-year-old impotence sufferer living in a retirement community in Florida, was impressed by Mr Dole's courage in coming forward.

“When I saw it on TV, I admired him for it,” he says.

“You might say he was my idol.”

Withdrawal of campaign

Pfizer decided not to use the term “impotence” in the advertisements, instead replacing it with a more bland technical term “erectile dysfunction”.

Pfizer's Mike Suesserman says the new term “allowed us to make the condition a household name”.

Pfizer reasoned that few men may admit to impotence, which employs a complete loss of ability, but a lot more may own up to erectile dysfunction, which suggests a much broader range of symptoms.

But Pfizer's aggressive marketing campaign has recently run into trouble.

A recent television advertisement has been criticized in the United States for suggesting that Viagra might be better and more effective for patients than the clinical experience suggests.

The Food and Drug Administration ordered its withdrawal.

Efficient sex

There are potential problems, too, in the increasing use of Viagra as a recreational drug.

Viagra medication
Half of all men over 40 become impotent at some point

“For a lot of gay people it is just a normal way of life,” says Gary Mercado, who runs the Elysium Resort, the largest gay hotel in Fort Lauderdale, Florida.

When Viagra is taken with amphetamines, “you forget about having protective sex, so there are huge capabilities of transmitting all sorts of sexual diseases”, he says.

Pfizer says that a very small percentage of people abuse Viagra, but accepts there is great potential in developing the market for sexual pharmaceuticals.

Meika Loe, author of the book The Rise of Viagra, agrees: “In the Viagra era, sexuality is subject to the cult of efficiency. It's become almost McDonald's-ised. Serve it up fast and hot.”

The Money Programme: Viagra: The Hard Sell was broadcast at 2200 GMT on Wednesday, 9 February on BBC Two .

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